{"product_id":"nsj-r31800-100ug","title":"MKK7 Antibody \/ MEK7 \/ MAP2K7, 100 ug","description":"\u003cp\u003eDual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase\/c-Jun N-terminal kinase (SAP\/JNK) signaling pathway. With MAP2K4\/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase\/c-Jun N-terminal kinases MAPK8\/JNK1, MAPK9\/JNK2 and MAPK10\/JNK3. MAP2K4\/MKK4 and MAP2K7\/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4\/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7\/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7\/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4\/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK\/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536578687200,"sku":"R31800","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_c0c52190-ee97-4225-98c9-c532009bc707.jpg?v=1768311676","url":"https:\/\/rndmate.com\/products\/nsj-r31800-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}