{"product_id":"nsj-rq8487-100ug","title":"JCHAIN Antibody \/ Immunoglobulin J chain, 100 ug","description":"\u003cp\u003eImmunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain \/ IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA, it induces larger polymers. Immunoglobulin J chain \/ IGJ also helps to bind these immunoglobulins to the secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain \/ IGJ is involved in creating the binding site for pIgR \/ SC in the Ig polymers, not only by determining the polymeric quaternary structure but also by interacting directly with the receptor protein. Both the immunoglobulin J chain \/ IGJ and the pIgR\/SC are key proteins in secretory immunity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536082284768,"sku":"RQ8487","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_bf2f7e87-5586-4374-b532-f74912a4fb16.jpg?v=1768301404","url":"https:\/\/rndmate.com\/products\/nsj-rq8487-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}