{"product_id":"nsj-v5111saf-100ug","title":"TIM-3 Antibody \/ HAVCR2, 100 ug","description":"\u003cp\u003eTIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser\/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ Th1 and CD8+ Tc1) but not on helper T cells (CD4+ Th2 and CD8+ Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48534587834592,"sku":"V5111SAF-100UG","price":559.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_118e6362-2623-44b4-abb3-2f84687b144f.jpg?v=1768281356","url":"https:\/\/rndmate.com\/products\/nsj-v5111saf-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}