{"product_id":"nsj-v5184saf-100ug","title":"IL22RA2 Antibody \/ Interleukin-22 receptor subunit alpha 2, 100 ug","description":"\u003cp\u003eIL-22RAlpha2 (Interleukin-22 receptor Alpha2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2- soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22RAlpha2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is 4- to 10-fold higher than that of the membrane-bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22RAlpha2 prevents the binding to the IL-22 membrane-bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22RAlpha2 may be important in regulating inflammatory responses. In addition, IL-22RAlpha2 can be induced by lipopolysaccharides (LPSs).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48534577709280,"sku":"V5184SAF-100UG","price":559.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_4efcf7b4-dfc7-4ce6-8e37-2151c49d9942.jpg?v=1768281062","url":"https:\/\/rndmate.com\/products\/nsj-v5184saf-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}