{"product_id":"nsj-v5737-100ug","title":"IDH1-R132G Antibody \/ Isocitrate Dehydrogenase R132G mutant, 100 ug","description":"\u003cp\u003eThe gene represented in this entry is involved in disease pathogenesis. Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.  Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48534424584416,"sku":"V5737-100UG","price":559.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_a83ddc92-6425-414e-aad4-c29cbf1e61c6.jpg?v=1768276273","url":"https:\/\/rndmate.com\/products\/nsj-v5737-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}