{"product_id":"nsj-v5822saf-100ug","title":"Recombinant SIGLEC3 Antibody \/ Sialic acid-binding Ig-like lectin 3 \/ CD33, 100 ug","description":"\u003cp\u003eRecognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48534414885088,"sku":"V5822SAF-100UG","price":559.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_07270cf5-acc1-4351-9779-b9323c688b17.jpg?v=1768275930","url":"https:\/\/rndmate.com\/products\/nsj-v5822saf-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}