{"product_id":"nsj-v5904-20ug","title":"GAD67 Antibody \/ GAD1 \/ Glutamate decarboxylase 1, 20ug","description":"\u003cp\u003eGlutamate decarboxylase 1 (GAD1), commonly known as GAD67, is a pyridoxal phosphate-dependent enzyme that catalyzes conversion of glutamate into gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter within the central nervous system. GAD1 expression is strongly associated with inhibitory neuronal populations and contributes to regulation of neuronal excitability, synaptic inhibition, cortical signaling balance, and neural circuit organization. GAD1 Antibody is useful for investigations involving inhibitory neurotransmitter biology, interneuron differentiation, GABAergic signaling pathways, and neurodevelopment-associated cellular regulation.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;GAD1 antibody, also referred to as GAD67 antibody and Glutamate decarboxylase 67 antibody in the literature, recognizes a predominantly cytoplasmic neuronal enzyme encoded on chromosome 2q31. GAD1 localizes mainly within neuronal soma and presynaptic compartments where it supports constitutive GABA synthesis required for inhibitory neurotransmission. Expression of GAD1 is enriched within inhibitory interneurons throughout cortical and subcortical neural tissues and has been associated with neurodevelopmental disorders, epilepsy, schizophrenia, neurodegeneration, and neural lineage-associated tumor biology.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;GAD1 Antibody \/ Glutamate Decarboxylase 1 Antibody (clone BICCN-GAD67-1A6) is uniquely positioned for studies involving GABAergic signaling pathways and inhibitory neuronal differentiation. This mouse monoclonal antibody demonstrates strong western blot and immunohistochemical detection together with HuProt(TM) microarray specificity validation against more than 19,000 full-length human proteins. The combined validation profile supports use of clone BICCN-GAD67-1A6 in investigations involving inhibitory neuronal lineage characterization, neurotransmitter-associated signaling pathways, and neurodevelopment-associated cellular regulation.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Analysis of HuProt(TM) microarrays containing more than 19,000 individually purified full-length human proteins demonstrated selective recognition of GAD1\/GAD67 by clone BICCN-GAD67-1A6. In HuProt(TM) analysis, the Z-score represents the strength of antibody binding signal relative to the overall array mean, while the S-score reflects target specificity relative to the next highest ranked protein signal. Elevated S-score separation supports preferential target recognition and reduced off-target binding across the tested human proteome. This specificity validation strategy supports reliable detection of inhibitory neurotransmitter-associated pathways in complex neural tissues.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;GAD1 contributes directly to inhibitory synaptic regulation through sustained GABA production required for suppression of excitotoxic signaling and maintenance of neuronal network balance. Because GAD1 expression is highly associated with inhibitory neuronal populations, it serves as an important marker for investigations involving interneuron organization, inhibitory cortical circuitry, and GABAergic neuronal differentiation. GAD1 additionally represents a useful marker in studies involving neural lineage-associated tumors and developmental neural signaling pathways.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;This GAD1 Antibody supports research involving GABA synthesis, inhibitory neurotransmitter signaling, interneuron differentiation, synaptic inhibition pathways, neural circuit organization, neurodevelopment-associated regulation, and GABAergic neuronal biology. Clone BICCN-GAD67-1A6 may be incorporated into western blot, immunohistochemistry, and tissue-based investigations examining inhibitory neural signaling pathways in normal and diseased tissues.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;For highly specific detection of GAD67 in inhibitory neurotransmitter pathway studies, see our \u0026lt;a href=..\/tds\/gad67-antibody-gad1-gad12391-v3854\u0026gt;GAD67 Antibody \/ GABA Synthesis Enzyme Antibody\u0026lt;\/a\u0026gt; page featuring strong HuProt(TM) microarray specificity validation data.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable style=\"width:100%;border-collapse:collapse;\"\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eCatalog No\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eV5904-20UG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eFamily\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003ePrimary antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eQty\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003e20ug\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eFormulation\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003e0.2 mg\/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eFormat\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003ePurified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eClone\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eBICCN-GAD67-1A6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eHost Animal\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eClonality\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eMonoclonal (mouse origin)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eIsotype\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eMouse IgG2c, kappa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eApplication\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eWB, IHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eApplication Details\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eWestern Blot: 2-4ug\/ml,Immunohistochemistry (FFPE): 1-2ug\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eApplication Note\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eOptimal dilution of the GAD1 Antibody \/ Glutamate Decarboxylase 1 Antibody should be determined by the researcher.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eStatus\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eAvailable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003ePDF Link\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003e\u003ca href=\"http:\/\/www.nsjbio.com\/tds-pdf\/gad1-antibody-glutamate-decarboxylase-1-biccn-gad67-1a6-v5904\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eProduct Data Sheet (PDF)\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eLimitation\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eThis GAD1 Antibody \/ Glutamate Decarboxylase 1 Antibody is available for research use only.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eUniprot #\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eQ99259\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eImmunogen\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eRecombinant human GAD1 (GAD67) protein (exact sequence is proprietary) was used as the immunogen for the GAD1 \/ Glutamate decarboxylase 1 antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eStorage\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eGAD1 \/ Glutamate decarboxylase 1 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eLocalization\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eCytoplasm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eTitle\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eGAD67 Antibody \/ GAD1 \/ Glutamate decarboxylase 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20ug","offer_id":67783010451680,"sku":"V5904-20UG","price":0.0,"currency_code":"KRW","in_stock":true}],"url":"https:\/\/rndmate.com\/products\/nsj-v5904-20ug","provider":"알앤디메이트","version":"1.0","type":"link"}