{"product_id":"nsj-v5911-100ug","title":"HLA-E Antibody \/ Nonclassical MHC class I molecule HLA-E, 100ug","description":"\u003cp\u003eNon-classical MHC class I antibody targets HLA class I histocompatibility antigen E, a specialized major histocompatibility complex class I molecule encoded by the HLA-E gene. Unlike classical MHC class I proteins such as HLA-A, HLA-B, and HLA-C, HLA-E exhibits limited polymorphism and serves predominantly immune regulatory functions rather than broad peptide antigen presentation. Non-classical MHC class I molecules are characterized by restricted peptide repertoires and distinct roles in immune surveillance, making a non-classical MHC class I antibody an important tool for immunology research.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;HLA class I histocompatibility antigen E is primarily expressed at the cell surface in association with beta-2 microglobulin and short peptides derived from the leader sequences of other HLA class I molecules. This peptide presentation enables HLA-E to interact with CD94 NKG2 receptor complexes on natural killer (NK) cells. Engagement of inhibitory receptors such as CD94 NKG2A transmits tolerance signals that prevent NK cell-mediated killing of healthy cells. Because of this mechanism, HLA-E is widely recognized as a key immune checkpoint molecule within the innate immune system. Use of a non-classical MHC class I antibody allows detailed study of NK cell inhibition and immune self-recognition pathways.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Beyond its role in NK cell regulation, HLA class I histocompatibility antigen E can present select pathogen-derived peptides to subsets of CD8-positive T cells, linking innate and adaptive immune responses. Expression of HLA-E is modulated by inflammatory cytokines, cellular stress, and infection, allowing dynamic adjustment of immune tolerance mechanisms. Viral pathogens, including cytomegalovirus, are known to exploit HLA-E upregulation as a strategy to evade immune clearance. A non-classical MHC class I antibody is therefore valuable for studies of host-pathogen interactions and immune evasion biology.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;HLA-E expression has significant relevance in cancer immunology. Many tumors increase expression of non-classical MHC class I molecules, including HLA-E, to suppress NK cell activity and escape immune surveillance. Elevated HLA-E levels have been reported across a range of solid tumors and hematologic malignancies, where they may contribute to immune suppressive tumor microenvironments. Use of a non-classical MHC class I antibody supports research into tumor immune escape mechanisms and the development of novel immunotherapeutic strategies targeting NK cell checkpoints.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Structurally, HLA class I histocompatibility antigen E shares the conserved alpha chain architecture of MHC class I proteins but differs in its peptide-binding groove, which accommodates a limited and conserved peptide set. This structural specialization underlies its unique immune regulatory function. Because non-classical MHC class I expression reflects immune modulation rather than antigen diversity, antibody-based detection of HLA-E is frequently used to assess immune regulatory status in tissues rather than classical antigen presentation capacity.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Clone HLAE\/13126 is designed to recognize HLA class I histocompatibility antigen E and supports detection of non-classical MHC class I expression in research applications. NSJ Bioreagents offers this non-classical MHC class I antibody to support studies of NK cell biology, immune tolerance, tumor immunology, and non-classical HLA function.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable style=\"width:100%;border-collapse:collapse;\"\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eCatalog No\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eV5911-100UG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eFamily\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003ePrimary antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eQty\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003e100ug\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eFormulation\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003e0.2 mg\/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eFormat\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003ePurified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eClone\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eHLAE\/13126\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eHost Animal\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eClonality\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eMonoclonal (mouse origin)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eIsotype\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eMouse IgG2, kappa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eApplication\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eWB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eApplication Details\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eWestern Blot: 2-4ug\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eApplication Note\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eOptimal dilution of the Non-classical MHC class I\/Nonclassical MHC class I molecule HLA-E antibody should be determined by the researcher.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eStatus\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eAvailable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003ePDF Link\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003e\u003ca href=\"http:\/\/www.nsjbio.com\/tds-pdf\/non-classical-mhc-class-i-antibody-nonclassical-mhc-class-i-molecule-hla-e-hlae-13126-v5911\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eProduct Data Sheet (PDF)\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eLimitation\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eThis Non-classical MHC class I\/Nonclassical MHC class I molecule HLA-E antibody is available for research use only.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eUniprot #\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eP13747\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eImmunogen\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eA recombinant fragment (around amino acids 1-150) of human HLAE protein (exact sequence is proprietary) was used as the immunogen for the Non-classical MHC class I\/Nonclassical MHC class I molecule HLA-E antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eStorage\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eNon-classical MHC class I\/Nonclassical MHC class I molecule HLA-E antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eLocalization\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eSecreted\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;vertical-align:top;padding:6px;border-bottom:1px solid #eee;\"\u003eTitle\u003c\/th\u003e\n\u003ctd style=\"padding:6px;border-bottom:1px solid #eee;\"\u003eHLA-E Antibody \/ Nonclassical MHC class I molecule HLA-E\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100ug","offer_id":67782941573344,"sku":"V5911-100UG","price":0.0,"currency_code":"KRW","in_stock":true}],"url":"https:\/\/rndmate.com\/products\/nsj-v5911-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}