{"product_id":"nsj-v8507-20ug","title":"Recombinant PD-ECGF Antibody \/ Thymidine Phosphorylase, 20 ug","description":"\u003cp\u003eRecognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP\/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP\/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":48534198059232,"sku":"V8507-20UG","price":259.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_5aa09d4b-c7f2-4526-9887-93d4d6a2cead.jpg?v=1768270409","url":"https:\/\/rndmate.com\/products\/nsj-v8507-20ug","provider":"알앤디메이트","version":"1.0","type":"link"}