{"product_id":"pdk1-polyclonal-antibody","title":"PDK1 polyclonal antibody","description":"\u003ch3 class=\"singleh3\"\u003eProduct Details\u003c\/h3\u003e\n\u003ctable class=\"productspecification\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ccolgroup\u003e\n\u003ccol width=\"214\"\u003e\n\u003ccol width=\"448\"\u003e\n\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eAlternative Name:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003ePyruvate dehydrogenase kinase\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eHost:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eImmunogen:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eSynthetic peptide corresponding to a portion of human PDK1 (Pyruvate dehydrogenase kinase-1).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eUniProt ID:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eQ15118\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eGenBank ID:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eL42450\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eSource:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003ePurified from rabbit serum.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eSpecies reactivity:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eHuman, Mouse, Rat\u003cbr\u003eDog, Monkey, Porcine, Rabbit\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eApplications:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eIHC (PS), WB\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eRecommended Dilutions\/Conditions:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eWestern Blot (1:1,000, ECL)\u003cbr\u003eSuggested dilutions\/conditions may not be available for all applications.\u003cbr\u003eOptimal conditions must be determined individually for each application.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eApplication Notes:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eDetects a band of ~48kDa by Western blot.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003ePurity Detail:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eProtein A affinity purified.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eFormulation:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eLiquid. In PBS containing 50% glycerol and 0.09% sodium azide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eShipping:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eBlue Ice\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eLong Term Storage:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003e-20°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eScientific Background:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003ePDK-1 (Pyruvate dehydrogenase kinase-1) is a 48 kDa protein kinase. It is a member of the mitrochondrial matrix protein kinase family and is related to the histidine protein kinases found in prokaryotes. PDK-1 is responsible for phosphorylation and concomitant inactivation of pyruvate dehydrogenase.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\"\u003e\u003cb\u003eRegulatory Status:\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd valign=\"top\"\u003eRUO - Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subitemruler\" colspan=\"2\"\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"primages\"\u003e\n\u003cdiv class=\"bigimg8214 productbimage\" id=\"defaultimg\"\u003e\n\u003cimg title=\"PDK1 polyclonal antibody Immunohistochemistry\" alt=\"PDK1 polyclonal antibody Immunohistochemistry\" src=\"https:\/\/www.enzolifesciences.com\/fileadmin\/files\/image\/KAP-PK112_IHC.jpg\"\u003e\u003cbr\u003e\n\u003cdiv class=\"literaturelegend\"\u003eImmunohistochemistry analysis of human spleen tissue stained with PDK1, pAb at 10µg\/ml.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003ePlease mouse over\u003c\/div\u003e\n\u003cdiv class=\"prodthumbs\"\u003e\n\u003cimg class=\"productimage\" title=\"PDK1 polyclonal antibody Immunohistochemistry\" alt=\"PDK1 polyclonal antibody Immunohistochemistry\" src=\"https:\/\/www.enzolifesciences.com\/fileadmin\/thumbs\/38dff8b8925476b054291edf4c97655ccb32457f-KAP-PK112_IHC.jpg.jpg\" id=\"thumb8214\" onmouseover=\"toggleimage('bigimg8214');\"\u003e\u003cimg class=\"productimage\" title=\"PDK1 polyclonal antibody Western blot\" alt=\"PDK1 polyclonal antibody Western blot\" src=\"https:\/\/www.enzolifesciences.com\/fileadmin\/thumbs\/5155f493a3dde9b4a94f1d9ccdf5e1618f4b685a-ADI-KAP-PK112_WB.jpg.jpg\" id=\"thumb6601\" onmouseover=\"toggleimage('bigimg6601');\"\u003e\u003cbr class=\"clearing\"\u003e\n\u003c\/div\u003e\n\u003ca name=\"Citations\"\u003e\u003c\/a\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003ch3 class=\"singleh3\"\u003eProduct Literature References\u003c\/h3\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eAndrographolide suppresses aerobic glycolysis and induces apoptotic cell death by inhibiting pyruvate dehydrogenase kinase 1 expression\u003c\/i\u003e: E.S. Yang, et al.; Oncol. Rep.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e49\u003c\/b\u003e, 72 (2023),\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36825595\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eInhibition of pyruvate dehydrogenase kinase 4 in CD4+ T cells ameliorates intestinal inflammation\u003c\/i\u003e: H. Lee, et al.; Cell. Mol. Gastroenterol. Hepatol.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e15\u003c\/b\u003e, 439 (2023),\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36229019\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eRational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma\u003c\/i\u003e: H. Lu, et al.; JCI Insight\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e4\u003c\/b\u003e, e131106 (2019),\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31578313\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/insight.jci.org\/articles\/view\/131106\" target=\"_blank\"\u003eFull Text\u003c\/a\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis\u003c\/i\u003e: H. Lu, et al.; Cancer Lett.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e381\u003c\/b\u003e, 23 (2016),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eApplication(s):\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eWestern blotting and Immunoprecipitation,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27450723\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eHypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours\u003c\/i\u003e: T. Golias, et al.; Sci. Rep.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e6\u003c\/b\u003e, 31146 (2016),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eApplication(s):\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eWestern blotting antibodies,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27498883\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.nature.com\/articles\/srep31146\" target=\"_blank\"\u003eFull Text\u003c\/a\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eMetabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis\u003c\/i\u003e: G.N. Valbuena, et al.; Mol. Neurobiol.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e53\u003c\/b\u003e, 2222 (2016),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eApplication(s):\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eWestern Blot,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25963727\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/link.springer.com\/article\/10.1007\/s12035-015-9165-7\/fulltext.html\" target=\"_blank\"\u003eFull Text\u003c\/a\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eOvercoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism\u003c\/i\u003e: Z. Ai, et al.; Cancer Lett.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e373\u003c\/b\u003e, 36 (2016),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eApplication(s):\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eWestern blot,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26801746\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.cancerletters.info\/article\/S0304-3835(16)00021-5\/fulltext\" target=\"_blank\"\u003eFull Text\u003c\/a\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eMethylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor kaiso\u003c\/i\u003e: C.C. Pierre, et al.; Biochim. Biophys. Acta\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e1849\u003c\/b\u003e, 1432 (2015),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eApplication(s):\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eImmunoblot analysis,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26514431\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003epVHL is a regulator of glucose metabolism and insulin secretion in pancreatic β cells\u003c\/i\u003e: W. Krek, et al. ; Genes Dev.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e22\u003c\/b\u003e, 3135 (2008),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eApplication(s):\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eWB using mouse cell lysates,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19056893\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003c\/div\u003e\n\u003cdiv class=\"litreference\"\u003e\n\u003ci\u003eDichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels\u003c\/i\u003e: S.L. Archer, et al. ; Circulation\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e105\u003c\/b\u003e, 244 (2002),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eApplication(s):\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eWB using rat samples,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11790708\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e;\u003c\/div\u003e\n\u003ca name=\"Related\"\u003e\u003c\/a\u003e\u003cspan\u003e\u003c\/span\u003e","brand":"Enzo Life Science","offers":[{"title":"Default Title","offer_id":44849821122784,"sku":"ADI-KAP-PK112-F","price":0.0,"currency_code":"KRW","in_stock":true}],"url":"https:\/\/rndmate.com\/products\/pdk1-polyclonal-antibody","provider":"알앤디메이트","version":"1.0","type":"link"}