{"product_id":"phospho-abl1-2-y393-439-polyclonal-antibody-bt-lab","title":"Phospho-Abl1\/2 (Y393\/439) Polyclonal Antibody","description":"\u003cp\u003eABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.\u003c\/p\u003e\n\u003cp\u003eThe PHOSPHO-ABL1\/2 (Y393\/439) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated ABL1 and ABL2 proteins. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target proteins.\u003cbr\u003e\u003cbr\u003eThe PHOSPHO-ABL1\/2 (Y393\/439) Polyclonal Antibody is ideal for various applications, including western blotting, immunoprecipitation, and immunofluorescence. It enables researchers to investigate the phosphorylation status of ABL1 and ABL2 proteins in different cellular contexts, providing valuable insights into their functional roles and signaling pathways.\u003cbr\u003e\u003cbr\u003eThis antibody exhibits exceptional performance in terms of sensitivity and specificity, allowing for accurate and reliable results. It recognizes the phosphorylated tyrosine residues at positions 393 and 439 of ABL1 and ABL2 proteins, respectively, with high selectivity, minimizing the risk of cross-reactivity with non-phosphorylated forms.\u003cbr\u003e\u003cbr\u003eThe PHOSPHO-ABL1\/2 (Y393\/439) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results. It is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation steps.\u003cbr\u003e\u003cbr\u003eIn summary, the PHOSPHO-ABL1\/2 (Y393\/439) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of phosphorylated ABL1 and ABL2 proteins. Its high specificity, sensitivity, and ease of use make it an invaluable asset for researchers studying the role of ABL1 and ABL2 in various biological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42358354542816,"sku":"BT-PHS00619","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_cd5accae-4751-457d-a2bd-8e41d8464066.png?v=1644580674","url":"https:\/\/rndmate.com\/products\/phospho-abl1-2-y393-439-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}