{"product_id":"ppx-monoclonal-antibody-bt-lab","title":"PPX Monoclonal Antibody","description":"\u003cp\u003ecatalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,function:Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2\/Cdk1 phosphorylation sites and negatively regulates CDC2\/Cdk1 activity in interphase.,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.,subunit:Serine\/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1\/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1\/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.,\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Mouse \/ Primary antibody","offer_id":42359472324832,"sku":"BT-MCA1055","price":300.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_bd3fc07a-60a5-41f1-ad28-e043ba6b3527.png?v=1644579503","url":"https:\/\/rndmate.com\/products\/ppx-monoclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}