{"product_id":"r31414","title":"DOG1 Antibody (TMEM16A)","description":"\u003cp\u003eAnoctamin-1 (ANO1), also known as oral cancer overexpressed 2 (ORAOV2), Tumor-amplified and overexpressed sequence 2 (TMEM16A), and Discovered on gastrointestinal stromal tumors protein 1 (DOG1) is a protein that in humans is encoded by the ANO1 gene. This gene belongs to a family of membrane proteins containing 8 transmembrane segments, and it is mapped to 11q13.3. ANO1 is a candidate calcium-activated chloride channel that mediates receptor-activated chloride currents in diverse physiologic processes, and it is though to be responsible for a voltage-sensitive calcium-activated chloride current. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression Crofelemer, an antidiarrhoeal, inhibits this channel. ANO1\/DOG1 has eight transmembrane domains, its pore is large and non-selective, allowing other negatively charged species to permeate.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":46768148185312,"sku":"R31414","price":439.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_855aa4de-e9d5-44c0-9657-14bf2c3ff7ea.jpg?v=1734482632","url":"https:\/\/rndmate.com\/products\/r31414","provider":"알앤디메이트","version":"1.0","type":"link"}