{"product_id":"tace-polyclonal-antibody-bt-lab","title":"TACE Polyclonal Antibody","description":"\u003cp\u003eADAM17 (ADAM metallopeptidase domain 17) encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of ADAM17 has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.\u003c\/p\u003e\n\u003cp\u003eThe TACE Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of TACE (Tumor Necrosis Factor-α Converting Enzyme) protein in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity.\u003cbr\u003e\u003cbr\u003eTACE, also known as ADAM17 (A Disintegrin And Metalloproteinase 17), is a key enzyme involved in the proteolytic processing of various cell surface proteins, including cytokines, growth factors, and receptors. It plays a crucial role in diverse physiological and pathological processes, such as inflammation, tissue remodeling, and cancer progression.\u003cbr\u003e\u003cbr\u003eThe TACE Polyclonal Antibody exhibits exceptional specificity, recognizing the target protein with minimal cross-reactivity to other related proteins. It has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody consistently delivers accurate and reproducible results, making it an ideal choice for both research and diagnostic applications.\u003cbr\u003e\u003cbr\u003eWith its high sensitivity, the TACE Polyclonal Antibody allows for the detection of low-abundance TACE protein levels, enabling researchers to study its expression patterns and regulation in different cell types and tissues. Its versatility and reliability make it an indispensable tool for investigating the role of TACE in various biological processes and disease conditions.\u003cbr\u003e\u003cbr\u003eThe TACE Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is available in different sizes to accommodate various experimental needs. Each batch of antibody undergoes rigorous quality control procedures to ensure consistent performance and batch-to-batch reproducibility.\u003cbr\u003e\u003cbr\u003eIn summary, the TACE Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and quantification of TACE protein. Its exceptional performance and versatility make it an invaluable asset for researchers and clinicians studying TACE-related processes and diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42358269313248,"sku":"BT-AP08786","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_7b518260-794b-4b73-a29e-a43115797e2d.png?v=1644580576","url":"https:\/\/rndmate.com\/products\/tace-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}