{"product_id":"tdp-43-recombinant-antibody-1","title":"TDP-43 Recombinant antibody","description":"\u003cdiv class=\"row collapse pt-60\" id=\"product-information\" data-section=\"product-information\" data-mce-fragment=\"1\"\u003e\n\u003csection class=\"product-information\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"small-12 medium-7 medium-offset-2 columns\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-section=\"tested-applications\" id=\"tested-applications\" class=\"row collapse pt-60\"\u003e\n\u003csection class=\"tested-applications\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"small-12 medium-7 medium-offset-2 columns\"\u003e\n\u003cdiv data-section=\"tested-applications\" id=\"tested-applications\" class=\"row collapse pt-60\"\u003e\n\u003csection class=\"tested-applications\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"small-12 medium-7 medium-offset-2 columns\"\u003e\n\u003ch3\u003eTested Applications\u003c\/h3\u003e\n\u003ctable class=\"mb-30 sm-block\" role=\"grid\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003ePositive WB detected in\u003c\/td\u003e\n\u003ctd\u003eHeLa cells, HAP1 cells, K-562 cells, Neuro-2a cells, C6 cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003ePositive IHC detected in\u003c\/td\u003e\n\u003ctd\u003ehuman gliomas tissue, spinal cord slides from ALS patients, frontal cortex from FTLD-TDP type B, mouse brain tissue, rat brain tissue\u003cbr\u003e\u003cstrong\u003e\u003ci\u003eNote: suggested antigen retrieval with\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"red\"\u003eTE buffer pH 9.0;\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e(*) Alternatively, antigen retrieval may be performed with\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"red\"\u003ecitrate buffer pH 6.0\u003c\/span\u003e\u003c\/i\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003ePositive IF detected in\u003c\/td\u003e\n\u003ctd\u003erat brain tissue, HAP1 cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003ePositive FC detected in\u003c\/td\u003e\n\u003ctd\u003eHeLa cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eRecommended dilution\u003c\/h3\u003e\n\u003ctable class=\"mb-0 sm-has-last-right-col\" role=\"grid\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eAPPLICATION\u003c\/th\u003e\n\u003cth\u003eDILUTION\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eWestern Blot (WB)\u003c\/td\u003e\n\u003ctd\u003eWB : 1:5000-1:50000\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eImmunohistochemistry (IHC)\u003c\/td\u003e\n\u003ctd\u003eIHC : 1:500-1:4000\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eImmunofluorescence (IF)\u003c\/td\u003e\n\u003ctd\u003eIF : 1:300-1:1200\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eFlow Cytometry (FC)\u003c\/td\u003e\n\u003ctd\u003eFC : 0.40 ug per 10^6 cells in a 100 µl suspension\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"red\" colspan=\"2\"\u003eIt is recommended that this reagent should be titrated in each testing system to obtain optimal results.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"red\" colspan=\"2\"\u003eSample-dependent, check data in validation data gallery\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cdiv data-section=\"published-applications\" id=\"published-applications\" class=\"row collapse pt-60\"\u003e\n\u003csection class=\"published-applications\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"small-12 medium-7 medium-offset-2 columns\"\u003e\n\u003ch3\u003ePublished Applications\u003c\/h3\u003e\n\u003ctable class=\"mb-0 sm-block\" role=\"grid\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eWB\u003c\/td\u003e\n\u003ctd\u003e\u003ca href=\"https:\/\/www.ptglab.com\/products\/TDP-43-Antibody-80001-1-RR.htm#publications\" class=\"green\"\u003eSee 1 publications below\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eIF\u003c\/td\u003e\n\u003ctd\u003e\u003ca href=\"https:\/\/www.ptglab.com\/products\/TDP-43-Antibody-80001-1-RR.htm#publications\" class=\"green\"\u003eSee 1 publications below\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eIP\u003c\/td\u003e\n\u003ctd\u003e\u003ca href=\"https:\/\/www.ptglab.com\/products\/TDP-43-Antibody-80001-1-RR.htm#publications\" class=\"green\"\u003eSee 1 publications below\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cdiv data-section=\"product-information\" id=\"product-information\" class=\"row collapse pt-60\"\u003e\n\u003csection class=\"product-information\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"small-12 medium-7 medium-offset-2 columns\"\u003e\n\u003ch3\u003eProduct Information\u003c\/h3\u003e\n\u003cp\u003e80001-1-RR targets TDP-43 in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with Human, mouse, rat samples.\u003c\/p\u003e\n\u003ctable class=\"mb-40 vert-top\" role=\"grid\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eTested Reactivity\u003c\/td\u003e\n\u003ctd\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eCited Reactivity\u003c\/td\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eHost \/ Isotype\u003c\/td\u003e\n\u003ctd\u003eRabbit \/ IgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eClass\u003c\/td\u003e\n\u003ctd\u003eRecombinant\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eType\u003c\/td\u003e\n\u003ctd\u003eAntibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd\u003efusion protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eFull Name\u003c\/td\u003e\n\u003ctd\u003eTAR DNA binding protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eCalculated molecular weight\u003c\/td\u003e\n\u003ctd\u003e43 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eObserved molecular weight\u003c\/td\u003e\n\u003ctd\u003e43 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eGenBank accession number\u003c\/td\u003e\n\u003ctd\u003e\u003ca rel=\"nofollow noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?term=BC001487\u0026amp;cmd=Search\u0026amp;db=nuccore\" class=\"blue\" target=\"_blank\"\u003eBC001487\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eGene symbol\u003c\/td\u003e\n\u003ctd\u003eTARDBP\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eGene ID (NCBI)\u003c\/td\u003e\n\u003ctd\u003e\u003ca rel=\"nofollow noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=gene\u0026amp;cmd=Retrieve\u0026amp;dopt=Graphics\u0026amp;list_uids=23435\" class=\"blue\" target=\"_blank\"\u003e23435\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eRRID\u003c\/td\u003e\n\u003ctd\u003eAB_2882933\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eConjugate\u003c\/td\u003e\n\u003ctd\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eForm\u003c\/td\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd\u003eProtein A purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eStorage Buffer\u003c\/td\u003e\n\u003ctd\u003ePBS with 0.02% sodium azide and 50% glycerol pH 7.3.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd\u003eStore at -20°C. Stable for one year after shipment.\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eAliquoting is unnecessary for -20\u003csup\u003eo\u003c\/sup\u003eC storage.\u003c\/span\u003e\u003cspan\u003e 20ul sizes contain 0.1% BSA.\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cdiv data-section=\"background-information\" id=\"background-information\" class=\"row collapse pt-60\"\u003e\n\u003csection class=\"product-backgroundinformation\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"small-12 medium-7 medium-offset-2 columns\"\u003e\n\u003ch3\u003eBackground Information\u003c\/h3\u003e\n\u003cdiv class=\"mb-30\"\u003e\n\u003cp\u003eThe TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing. For instance, it is reported to regulate alternate splicing of the CTFR gene. In 2006 Neumann et al. found that hyperphosphorylated, ubiquitinated and\/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS). Proteintech's 80001-1-RR is a rabbit recombinant TDP-43 antibody recognizing N-terminal TDP-43. It recognizes the intact 43 kDa protein as well as all posttranslationally modified and truncated forms in multiple applications. Various forms of TDP-43 exist, including 18-35 kDa of cleaved C-terminal fragments, 45-50 kDa phospho-protein, 55 kDa glycosylated form, 75 kDa hyperphosphorylated form, and 90-300 kDa cross-linked form. (PMID: 17023659, 19823856, 21666678, 22193176) Recently TDP-43 has been reported to be overexpressed in triple negative breast cancer (TNBC) and it may be a potential target for TNBC diagnosis and drug design. (PMID: 29581274).\u003cbr\u003e\u003cbr\u003e80001-1-RR can be used in WB, IHC, IHF. For the ICC (IF with cells) experiment, the results will be better with ethanol fixed cell and dilution 1:50 or 1:100. Another antibody with CatNo. 80002-1-RR is recommended for IF or ICC experiment.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cdiv data-section=\"protocols\" id=\"protocols\" class=\"row collapse pt-60\"\u003e\n\u003csection id=\"protocols\" class=\"protocols\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"small-12 medium-7 medium-offset-2 columns\"\u003e\n\u003ch3\u003eProtocols\u003c\/h3\u003e\n\u003ctable class=\"sm-block\" role=\"grid\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003ePRODUCT SPECIFIC PROTOCOLS\u003c\/th\u003e\n\u003cth\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle blue\"\u003eWB protocol for TDP-43 antibody 80001-1-RR\u003c\/td\u003e\n\u003ctd\u003e\u003ca rel=\"nofollow noopener\" href=\"https:\/\/www.ptglab.com\/products\/protocoljump.htm?catno=80001-1-RR\u0026amp;AppType=WB\" class=\"green\" target=\"_blank\"\u003eDownload protocol\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle blue\"\u003eIHC protocol for TDP-43 antibody 80001-1-RR\u003c\/td\u003e\n\u003ctd\u003e\u003ca rel=\"nofollow noopener\" href=\"https:\/\/www.ptglab.com\/products\/protocoljump.htm?catno=80001-1-RR\u0026amp;AppType=IHC\" class=\"green\" target=\"_blank\"\u003eDownload protocol\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"subtitle blue\"\u003eIF protocol for TDP-43 antibody 80001-1-RR\u003c\/td\u003e\n\u003ctd\u003e\u003ca rel=\"nofollow noopener\" href=\"https:\/\/www.ptglab.com\/products\/protocoljump.htm?catno=80001-1-RR\u0026amp;AppType=IF\" class=\"green\" target=\"_blank\"\u003eDownload protocol\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable class=\"m-0\" role=\"grid\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eSTANDARD PROTOCOLS\u003c\/th\u003e\n\u003cth\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ptglab.com\/support\/protocols\/\" class=\"green\"\u003eClick here to view our Standard Protocols\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cdiv data-section=\"protocols\" id=\"protocols\" class=\"row collapse pt-60\"\u003e\n\u003csection id=\"protocols\" class=\"protocols\"\u003e\n\u003cdiv class=\"row\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row collapse pt-60\" id=\"protocols\" data-section=\"protocols\" data-mce-fragment=\"1\"\u003e\n\u003csection class=\"protocols\" id=\"protocols\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"row\" data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e","brand":"PROTEINTECH","offers":[{"title":"Default Title","offer_id":44966456328416,"sku":"80001-1-RR","price":0.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/TDP-43-Antibody-80001-1-RR-WB-190345.webp?v=1710440933","url":"https:\/\/rndmate.com\/products\/tdp-43-recombinant-antibody-1","provider":"알앤디메이트","version":"1.0","type":"link"}