{"product_id":"v7019ihc-7ml","title":"EGF Receptor \/ EGFR Antibody","description":"\u003cp\u003eReceptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA\/TGF-alpha, amphiregulin, epigen\/EPGN, BTC\/betacellulin, epiregulin\/EREG and HBEGF\/heparin-binding EGF. Ligand binding triggers receptor homo- and\/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1\/beta-catenin. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"7 ml \/ Mouse","offer_id":46705125720288,"sku":"V7019IHC-7ML","price":539.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_00ce9d36-382a-429b-864a-45e267c6f742.jpg?v=1733345750","url":"https:\/\/rndmate.com\/products\/v7019ihc-7ml","provider":"알앤디메이트","version":"1.0","type":"link"}