{"product_id":"v7070ihc-7ml","title":"Thymidylate Synthase Antibody","description":"\u003cp\u003eThymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"7 ml \/ Mouse","offer_id":46705109565664,"sku":"V7070IHC-7ML","price":539.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_bb37f421-8417-4068-81aa-7fb78693946d.jpg?v=1733345320","url":"https:\/\/rndmate.com\/products\/v7070ihc-7ml","provider":"알앤디메이트","version":"1.0","type":"link"}