{"product_id":"v8338saf-100ug","title":"HPV-16 E1\/E4 Antibody","description":"\u003cp\u003eThe human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1\/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1\/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1\/cyclin B1 complexes. HPV16E1\/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1\/E4 is able to prevent mitotic entry. HPV16E1\/E4 also associates with keratin intermediate filaments and causes the network to collapse.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":46703023194336,"sku":"V8338SAF-100UG","price":539.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_6efcb623-75c1-4e4e-8289-57f5ed018dca.jpg?v=1733310754","url":"https:\/\/rndmate.com\/products\/v8338saf-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}