{"product_id":"v9714-20ug","title":"B-cell lymphoma\/leukemia 11A Antibody \/ BCL11A","description":"\u003cp\u003eBcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)\/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL\/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug \/ Mouse","offer_id":46702579122400,"sku":"V9714-20UG","price":249.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_795a3ee3-08bb-41d2-8c64-90e5b0c738ef.jpg?v=1733300520","url":"https:\/\/rndmate.com\/products\/v9714-20ug","provider":"알앤디메이트","version":"1.0","type":"link"}