아래 표는 식품의약품안전처 「화장품 중 배합금지성분 분석법 가이드라인」에 수록된 분석대상 성분을 기준으로 시험에 필요한 표준품과 내부표준물질을 정리한 것입니다.
참고: 추천 제조사는 식약처 가이드라인에 지정된 제조사가 아니며, 분석용 표준품 및 CRM 소싱 시 검토할 수 있는 제조사 후보입니다. 실제 구매 시 제품의 인증범위, 농도, 용매, 순도, CRM 여부 및 Certificate를 확인해야 합니다.
1. 일반 배합금지성분 및 분석용 표준품
| 성분명 | CAS No. | 분석법 | 필요한 표준품 · 내부표준품 | 추천 제조사 |
|---|---|---|---|---|
| 1,4-Dioxane | 123-91-1 | Headspace GC | 1,4-Dioxane Standard | AccuStandard / LGC Standards / Supelco |
| Benzoyl Peroxide | 94-36-0 | HPLC-UV | Benzoyl Peroxide Standard | LGC Standards / Supelco |
| Benzene | 71-43-2 | Headspace GC-MS | Benzene Standard | AccuStandard / LGC Standards / Supelco |
| Antimony | 7440-36-0 | ICP-MS | Antimony ICP Standard Solution | AccuStandard / SPEX CertiPrep / CPAchem |
| Cadmium | 7440-43-9 | ICP-MS | Cadmium Standard Solution | AccuStandard / SPEX CertiPrep / CPAchem |
| Formaldehyde | 50-00-0 | HPLC | Formaldehyde Standard | AccuStandard / LGC Standards / Supelco |
| Dibutyl Phthalate (DBP) | 84-74-2 | GC / GC-MS | DBP Standard GC 내부표준: Benzyl Benzoate GC-MS 내부표준: Fluoranthene-d10 |
AccuStandard / LGC Standards / Supelco |
| Benzyl Butyl Phthalate (BBP) | 85-68-7 | GC / GC-MS | BBP Standard GC 내부표준: Benzyl Benzoate GC-MS 내부표준: Fluoranthene-d10 |
AccuStandard / LGC Standards / Supelco |
| Bis(2-ethylhexyl) Phthalate (DEHP) | 117-81-7 | GC / GC-MS | DEHP Standard GC 내부표준: Benzyl Benzoate GC-MS 내부표준: Fluoranthene-d10 |
AccuStandard / LGC Standards / Supelco |
| Safrole | 94-59-7 | GC-MS | Safrole Standard 내부표준: Benzyl Chloride |
AccuStandard / LGC Standards |
| Diethylene Glycol | 111-46-6 | GC-MS | Diethylene Glycol Standard 내부표준: Benzyl Chloride |
AccuStandard / LGC Standards / Supelco |
| Dichlorophene | 97-23-4 | HPLC-UV | Dichlorophene Standard | LGC Standards / Supelco |
| N-Nitrosodiethanolamine (NDELA) | 1116-54-7 | UPLC-MS/MS | N-Nitrosodiethanolamine Standard 내부표준: N-Nitrosodiethanolamine-d8 |
LGC Standards / AccuStandard / TRC |
| Molinate | 2212-67-1 | GC-MS | Molinate Standard | AccuStandard / LGC Standards |
| Heptachlor | 76-44-8 | GC-MS | Heptachlor Standard | AccuStandard / LGC Standards |
| Fenthion | 55-38-9 | GC-MS | Fenthion Standard | AccuStandard / LGC Standards |
| Myclobutanil | 88671-89-0 | GC-MS | Myclobutanil Standard | AccuStandard / LGC Standards |
| Fenarimol | 60168-88-9 | GC-MS | Fenarimol Standard | AccuStandard / LGC Standards |
| Diphenylamine | 122-39-4 | GC-MS | Diphenylamine Standard | AccuStandard / LGC Standards |
| Vinclozolin | 50471-44-8 | GC-MS | Vinclozolin Standard | AccuStandard / LGC Standards |
| Aldrin | 60-57-1* | GC-MS | Aldrin Standard | AccuStandard / LGC Standards |
| Dieldrin | 60-57-1* | GC-MS | Dieldrin Standard | AccuStandard / LGC Standards |
| Captafol | 2425-06-1 | GC-MS | Captafol Standard | AccuStandard / LGC Standards |
| Carbaryl | 63-25-2 | HPLC-UV | Carbaryl Standard | AccuStandard / LGC Standards / Supelco |
| Bisphenol A | 80-05-7 | HPLC-FLD | Bisphenol A Standard 내부표준: 4-tert-Butylphenol |
AccuStandard / LGC Standards / Supelco |
| Acetonitrile | 75-05-8 | Headspace GC | Acetonitrile Standard 내부표준: 1,4-Dioxane-d8 |
AccuStandard / LGC Standards |
| Xylene | 1330-20-7-2* o-Xylene: 95-47-6 m-Xylene: 108-38-3 p-Xylene: 106-42-3 |
GC | Xylene Standard 내부표준: Benzyl Chloride |
AccuStandard / LGC Standards / Supelco |
| Hexavalent Chromium, Cr(VI) | 18540-29-9 | Ion Chromatography / UV 530 nm | Hexavalent Chromium Standard Solution, 1000 µg/mL | SPEX CertiPrep / AccuStandard / CPAchem |
| Minoxidil | 38304-91-5 | HPLC / LC-MS | Minoxidil Standard | LGC Standards / Supelco |
| Ciprofloxacin | 85721-33-1 | LC-MS | Ciprofloxacin Standard | LGC Standards / Supelco |
| Ciprofloxacin Hydrochloride Hydrate | 86393-32-0 | LC-MS | Ciprofloxacin Standard | LGC Standards / Supelco |
| HICC1 | 51414-25-6 | GC-MS | Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde Standard | LGC Standards |
| HICC2 | 31906-04-4 | GC-MS | Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde Standard | LGC Standards |
| Atranol | 526-37-4 | UPLC-MS/MS | Atranol Standard | LGC Standards |
| Chloroatranol | 57074-21-2 | UPLC-MS/MS | Chloroatranol Standard | LGC Standards |
| 4,4'-Diamino-2,2'-stilbenedisulfonic acid (DAD) | 81-11-8 | HPLC | DAD Standard | LGC Standards / Supelco |
| Umbelliferone | 93-35-6 | HPLC | Umbelliferone Standard | LGC Standards / Supelco |
| Disodium 4,4'-Bis(2-sulfonatostyryl)biphenyl (CBS-X) | 27344-41-8 | HPLC | CBS-X Standard | LGC Standards 등 소싱 확인 |
| Fluorescent Brightener 71 (DMA-X) | 16090-02-1 | HPLC | Fluorescent Brightener 71 Standard | LGC Standards 등 소싱 확인 |
2. Glucocorticoid 분석용 표준품
글루코코르티코이드 분석은 LC-MS/MS를 이용하며, 가이드라인에 수록된 개별 성분의 표준품을 이용해 검량선용 표준액을 조제합니다.
공통 내부표준물질: Triamcinolone-6-d1 Acetonide-d6
| 성분명 | CAS No. | 분석법 | 필요한 표준품 · 내부표준품 | 추천 제조사 |
|---|---|---|---|---|
| Amcinonide | 51022-69-6 | LC-MS/MS | Amcinonide Standard | LGC Standards / Supelco / TRC |
| Beclomethasone | 4419-39-0 | LC-MS/MS | Beclomethasone Standard | LGC Standards / TRC |
| Beclomethasone-21-acetate | 4735-64-2 | LC-MS/MS | Beclomethasone-21-acetate Standard | LGC Standards / TRC |
| Beclomethasone-17-propionate | 5534-18-9 | LC-MS/MS | Beclomethasone-17-propionate Standard | LGC Standards / TRC |
| Beclomethasone-21-propionate | 69224-79-9 | LC-MS/MS | Beclomethasone-21-propionate Standard | LGC Standards / TRC |
| Beclomethasone-21-hemisuccinate | 75899-57-9 | LC-MS/MS | Beclomethasone-21-hemisuccinate Standard | LGC Standards / TRC |
| Beclomethasone Dipropionate | 5534-09-8 | LC-MS/MS | Beclomethasone Dipropionate Standard | LGC Standards / Supelco |
| Betamethasone | 378-44-9 | LC-MS/MS | Betamethasone Standard | LGC Standards / Supelco |
| Betamethasone-21-acetate | 987-24-6 | LC-MS/MS | Betamethasone-21-acetate Standard | LGC Standards / TRC |
| Betamethasone-17-valerate | 2152-44-5 | LC-MS/MS | Betamethasone-17-valerate Standard | LGC Standards / TRC |
| Betamethasone-21-valerate | 2240-28-0 | LC-MS/MS | Betamethasone-21-valerate Standard | LGC Standards / TRC |
| Betamethasone Succinate | 27297-42-3 | LC-MS/MS | Betamethasone Succinate Standard | LGC Standards / TRC |
| Betamethasone Dipropionate | 5593-20-4 | LC-MS/MS | Betamethasone Dipropionate Standard | LGC Standards / Supelco |
| Budesonide | 51333-22-3 | LC-MS/MS | Budesonide Standard | LGC Standards / Supelco |
| Clobetasol-17-propionate | 25122-46-7 | LC-MS/MS | Clobetasol Propionate Standard | LGC Standards / Supelco |
| Clobetasone Butyrate | 25122-57-0 | LC-MS/MS | Clobetasone Butyrate Standard | LGC Standards / TRC |
| Cortisone-21-acetate | 50-04-4 | LC-MS/MS | Cortisone-21-acetate Standard | LGC Standards / TRC |
| Dexamethasone | 50-02-2 | LC-MS/MS | Dexamethasone Standard | LGC Standards / Supelco |
| Dexamethasone-21-acetate | 1177-87-3 | LC-MS/MS | Dexamethasone-21-acetate Standard | LGC Standards / TRC |
| Dexamethasone-21-hemisuccinate | 3800-86-0 | LC-MS/MS | Dexamethasone-21-hemisuccinate Standard | LGC Standards / TRC |
| Dichlorisone Acetate | 79-61-8 | LC-MS/MS | Dichlorisone Acetate Standard | LGC Standards / TRC |
| Diflorasone Diacetate | 33564-31-7 | LC-MS/MS | Diflorasone Diacetate Standard | LGC Standards / TRC |
| Fludrocortisone Acetate | 514-36-3 | LC-MS/MS | Fludrocortisone Acetate Standard | LGC Standards / TRC |
| Fluocinolone Acetonide | 67-73-2 | LC-MS/MS | Fluocinolone Acetonide Standard | LGC Standards / Supelco |
| Flurandrenolide | 1524-88-5 | LC-MS/MS | Flurandrenolide Standard | LGC Standards / TRC |
| Fluticasone Propionate | 80474-14-2 | LC-MS/MS | Fluticasone Propionate Standard | LGC Standards / TRC |
| Hydrocortisone | 50-23-7 | LC-MS/MS | Hydrocortisone Standard | LGC Standards / Supelco |
| Hydrocortisone-17-acetate | 16463-74-4 | LC-MS/MS | Hydrocortisone-17-acetate Standard | LGC Standards / TRC |
| Hydrocortisone-21-acetate | 50-03-3 | LC-MS/MS | Hydrocortisone-21-acetate Standard | LGC Standards / Supelco |
| Hydrocortisone-17-valerate | 57524-89-7 | LC-MS/MS | Hydrocortisone-17-valerate Standard | LGC Standards / TRC |
| Hydrocortisone-21-valerate | 6678-00-8 | LC-MS/MS | Hydrocortisone-21-valerate Standard | LGC Standards / TRC |
| Hydrocortisone-17-butyrate | 13609-67-1 | LC-MS/MS | Hydrocortisone-17-butyrate Standard | LGC Standards / TRC |
| Hydrocortisone-21-hemisuccinate | 2203-97-6 | LC-MS/MS | Hydrocortisone-21-hemisuccinate Standard | LGC Standards / TRC |
| Mometasone Furoate | 83919-23-7 | LC-MS/MS | Mometasone Furoate Standard | LGC Standards / Supelco |
| Prednisolone | 50-24-8 | LC-MS/MS | Prednisolone Standard | LGC Standards / Supelco |
| Prednisolone-21-acetate | 52-21-1 | LC-MS/MS | Prednisolone-21-acetate Standard | LGC Standards / TRC |
| Prednisone-21-acetate | 125-10-0 | LC-MS/MS | Prednisone-21-acetate Standard | LGC Standards / TRC |
| Triamcinolone Acetonide | 76-25-5 | LC-MS/MS | Triamcinolone Acetonide Standard | LGC Standards / Supelco |
| Triamcinolone Diacetate | 67-78-7 | LC-MS/MS | Triamcinolone Diacetate Standard | LGC Standards / TRC |
| 6α-Methylprednisolone | 83-43-2 | LC-MS/MS | 6α-Methylprednisolone Standard | LGC Standards / TRC |
| 6α-Methylprednisolone Aceponate | 86401-95-8 | LC-MS/MS | 6α-Methylprednisolone Aceponate Standard | LGC Standards / TRC |
| Fluticasone Furoate | 397864-44-7 | LC-MS/MS | Fluticasone Furoate Standard | LGC Standards / TRC |
| Prednisone | 53-03-2 | LC-MS/MS | Prednisone Standard | LGC Standards / Supelco |
3. 주요 내부표준물질 별도 정리
| 적용 분석 | 내부표준물질 | 분석법 | 추천 제조사 |
|---|---|---|---|
| Glucocorticoids | Triamcinolone-6-d1 Acetonide-d6 | LC-MS/MS | LGC Standards / TRC |
| Phthalates | Benzyl Benzoate | GC-FID | AccuStandard / LGC Standards / Supelco |
| Phthalates | Fluoranthene-d10 | GC-MS | AccuStandard / LGC Standards |
| Safrole | Benzyl Chloride | GC-MS | AccuStandard / LGC Standards |
| Diethylene Glycol | Benzyl Chloride | GC-MS | AccuStandard / LGC Standards |
| N-Nitrosodiethanolamine | N-Nitrosodiethanolamine-d8 | UPLC-MS/MS | LGC Standards / TRC |
| Bisphenol A | 4-tert-Butylphenol | HPLC-FLD | LGC Standards / Supelco |
| Acetonitrile | 1,4-Dioxane-d8 | Headspace GC | LGC Standards / TRC |
| Xylene | Benzyl Chloride | GC | AccuStandard / LGC Standards |
화장품 분석용 표준품을 찾고 계신가요?
분석 대상 성분명 또는 CAS No.를 보내주시면 알앤디메이트에서 여러 글로벌 제조사의 Analytical Standard, CRM, ICP Standard 및 Isotope-Labeled Internal Standard를 확인해 드립니다.
여러 성분이 포함된 시험법의 경우 필요한 표준품 목록 전체를 보내주셔도 됩니다.
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※ 본 표는 식품의약품안전처 「화장품 중 배합금지성분 분석법 가이드라인(민원인 안내서)」을 참고하여 작성한 정보성 자료입니다. 실제 시험 및 제품 선정 시 최신 관련 고시와 시험법, 표준품의 인증범위 및 Certificate를 확인하시기 바랍니다.
* Aldrin/Dieldrin의 CAS 번호 및 Xylene 혼합물 CAS 표기는 첨부 가이드라인의 표기를 기준으로 작성하였으며, 실제 제품 선정 시 개별 성분의 CAS 번호를 추가 확인하시기 바랍니다.