A20 (A-12)

A20 Antibody (A-12) is a high quality monoclonal A20 antibody (also designated TNFAIP3 antibody, or TNF a induced protein 3 antibody). A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor k B (NFkB) gene expression. By inhibiting NFkB activation, A20 plays a critical role in terminating NFkB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFkB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) g protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.