anti- ABCA4 antibody

Delve into the intricacies of vision and retinal health with our Anti-ABCA4 Antibody, available in a 100µg size. ABCA4, also known as the ATP-binding cassette subfamily A member 4, is a critical transporter protein located in the photoreceptor cells of the retina. Investigating the function of ABCA4 is essential for understanding the molecular mechanisms underlying inherited retinal diseases, including Stargardt disease and certain forms of retinitis pigmentosa.

Our meticulously designed antibody is tailored to specifically target ABCA4 with exceptional specificity and sensitivity, enabling precise detection and quantification in various research applications. Whether you are studying the role of ABCA4 in retinal lipid transport, exploring its association with retinal degeneration, or investigating therapeutic strategies to modulate ABCA4 activity, this antibody empowers you to make meaningful discoveries.

Product Name

ABCA4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

IMMUNOGEN INFORMATION

Immunogen

ABCA4

Synonyms

ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1

Observed MW

256 kDa

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P78363

IMAGES

Immunohistochemistry of paraffin-embedded human colon cancer using FNab10057(ABCA4 antibody) at dilution of 1:100