anti- CD320 antibody

Step into the realm of vitamin B12 (cobalamin) research with our Anti-CD320 Antibody, now available in a 100µg size. CD320, also known as transcobalamin receptor (TCblR), is essential for cellular uptake of cobalamin, a critical nutrient involved in various physiological processes, including DNA synthesis and nervous system function.

This monoclonal antibody offers high specificity and sensitivity, making it an indispensable tool for researchers investigating cobalamin transport and metabolism. With 100µg of this antibody, you'll have a substantial supply for multiple experiments, ensuring the uninterrupted progression of your research.

Explore the intricate mechanisms governing cobalamin uptake, cellular cobalamin utilization, and the role of CD320 in maintaining cobalamin homeostasis. Investigate how CD320 impacts human health, particularly in the context of vitamin B12 deficiency and related disorders.

Product Name

CD320 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CD320, also known as 8D6, 8D6A or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC). CD320 has a calculated molecular mass of 29 kDa. This antibody detects bands at 50-55 kDa and 60-70 kDa, probably caused by extensive complex glycosylation.

IMMUNOGEN INFORMATION

Immunogen

CD320 molecule

Synonyms

8D6, 8D6 antigen, 8D6A, CD320, CD320 antigen, CD320 molecule, FDC signaling molecule 8D6, FDC SM 8D6, TCblR, Transcobalamin receptor

Observed MW

50-55 kDa, 60-70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NPF0

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