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FineTest

SKU(재고 관리 코드):FNab04765

anti- LGR5 antibody

anti- LGR5 antibody

size

anti- LGR5 antibody

Product Name

LGR5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

IMMUNOGEN INFORMATION

Immunogen

leucine-rich repeat-containing G protein-coupled receptor 5

Synonyms

FEX, G protein coupled receptor 49, G protein coupled receptor 67, GPR49, GPR67, GRP49, HG38, LGR5

Observed MW

92-120kd

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:100-1:400

UNIPROT INFORMATION

UniProt ID

O75473

IMAGES

Immunohistochemical of paraffin-embedded human small intestine using FNab04765(LGR5 antibody) at dilution of 1:200

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab04765(LGR5 antibody) at dilution of 1:1000

 

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