FineTest
SKU(재고 관리 코드):FNab04765
anti- LGR5 antibody
anti- LGR5 antibody
anti- LGR5 antibody
Product Name
LGR5 antibody
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BACKGROUND
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
IMMUNOGEN INFORMATION
Immunogen
leucine-rich repeat-containing G protein-coupled receptor 5
Synonyms
FEX, G protein coupled receptor 49, G protein coupled receptor 67, GPR49, GPR67, GRP49, HG38, LGR5
Observed MW
92-120kd
APPLICATION
Tested Application
ELISA, WB, IHC
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:100-1:400
UNIPROT INFORMATION
UniProt ID
IMAGES
Immunohistochemical of paraffin-embedded human small intestine using FNab04765(LGR5 antibody) at dilution of 1:200
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab04765(LGR5 antibody) at dilution of 1:1000