anti- ZIP kinase antibody

Product Name

ZIP kinase antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ZIP kinase, also named as ZIPK and Dlk, belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. ZIP kinase is a Serine/threonine kinase which acts as a positive regulator of apoptosis. ZIP kinasephosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. ZIP kinase regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It catalyze the reaction: ATP + a protein = ADP + a phosphoprotein.

IMMUNOGEN INFORMATION

Immunogen

death-associated protein kinase 3

Synonyms

DAP kinase 3, DAP like kinase, DAPK3, Dlk, ZIP kinase, ZIPK

Observed MW

53kd

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:200-1:1000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O43293

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