HER2/neu (c-erbB-2)

This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a subset of breast and other adenocarcinomas, as well astransitional cell carcinomas. In the case of breast cancer, expression determined byimmunohistochemistry has been shown to be associated with poor prognosis.