Histone H2A(Phospho Ser129) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

The Histone H2A(Phospho Ser129) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Serine 129 residue on Histone H2A. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H2A is a crucial component of nucleosomes, which are the basic units of chromatin structure. Phosphorylation of Serine 129 on Histone H2A has been implicated in various cellular processes, including DNA damage response, cell cycle regulation, and apoptosis. Therefore, the detection and quantification of phosphorylated Serine 129 on Histone H2A is of great importance in understanding these biological processes.

The Histone H2A(Phospho Ser129) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Serine 129 on Histone H2A in various sample types.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The Histone H2A(Phospho Ser129) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

In summary, the Histone H2A(Phospho Ser129) Polyclonal Antibody is a valuable tool for researchers studying the role of phosphorylated Serine 129 on Histone H2A in various biological processes. Its high specificity, sensitivity, and ease of use make it an ideal choice for reliable and accurate detection and analysis.