IL-10R alpha(Phospho Tyr496) Polyclonal Antibody

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

The IL-10R alpha(Phospho Tyr496) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of IL-10R alpha protein phosphorylated at tyrosine 496. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

IL-10R alpha is a crucial receptor involved in the signaling pathway of interleukin-10 (IL-10), a potent anti-inflammatory cytokine. Phosphorylation of tyrosine 496 in IL-10R alpha has been shown to play a significant role in the regulation of IL-10 signaling and downstream cellular responses.

The IL-10R alpha(Phospho Tyr496) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and selectivity, enabling accurate detection and quantification of phosphorylated IL-10R alpha in complex biological samples.

This antibody is manufactured using high-quality materials and stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

Researchers and scientists in the fields of immunology, cell biology, and signal transduction will greatly benefit from the IL-10R alpha(Phospho Tyr496) Polyclonal Antibody, as it provides a valuable tool for investigating the intricate mechanisms underlying IL-10 signaling and its implications in various physiological and pathological processes.

In summary, the IL-10R alpha(Phospho Tyr496) Polyclonal Antibody is a reliable and specific reagent that enables accurate detection and analysis of phosphorylated IL-10R alpha. Its high performance and versatility make it an indispensable tool for researchers aiming to unravel the complexities of IL-10 signaling and its associated biological functions.