MASP1 Rabbit Polyclonal Antibody

enzyme regulation:Inhibited by SERPING1 and A2M.|Functions in the lectin pathway of complement| which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.|PTM:Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond.

Isoform 1 but not isoform 2 is activated through autoproteolytic processing.|PTM:N-glycosylated. Some N-linked glycan are of the complex-type.|PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.|Belongs to the peptidase S1 family.|Contains 1 EGF-like domain

.|Contains 1 peptidase S1 domain.|Contains 2 CUB domains.|Contains 2 Sushi (CCP/SCR) domains.|subunit:Homodimer. Interacts with the oligomeric lectins MBL2| FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.|tissue specificity:Protein of the plasma which is primarily expressed by liver.|

The MASP1 Rabbit Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of MASP1 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, resulting in a high affinity and specificity towards MASP1.

With its exceptional sensitivity, this antibody enables accurate and precise analysis of MASP1 expression levels in both research and diagnostic applications. It exhibits minimal cross-reactivity with other related proteins, ensuring reliable and specific results.

The MASP1 Rabbit Polyclonal Antibody is produced using state-of-the-art purification methods, guaranteeing a high purity and low background signal. Its robust performance and consistent quality make it an ideal choice for various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence.

Furthermore, this antibody has been extensively validated in multiple experimental settings, ensuring its reliability and reproducibility. It is supplied in a convenient and user-friendly format, allowing for easy handling and storage.

In summary, the MASP1 Rabbit Polyclonal Antibody is a valuable tool for researchers and clinicians alike, offering exceptional sensitivity, specificity, and reliability in the detection and quantification of MASP1 protein. Its high-quality formulation and extensive validation make it an indispensable asset in various biological studies and diagnostic applications.