MKP-1/2(Phospho Ser296/318) Polyclonal Antibody

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.  It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.  The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.  Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.  Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferati

The MKP-1/2(Phospho Ser296/318) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of MKP-1 and MKP-2 proteins phosphorylated at Ser296 and Ser318 residues. This antibody has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The MKP-1/2(Phospho Ser296/318) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated forms of MKP-1 and MKP-2, enabling accurate and reliable detection of these proteins in complex biological samples. Its high sensitivity ensures the detection of even low abundance targets, making it an ideal choice for both qualitative and quantitative analysis.

This antibody has been extensively characterized and validated using a variety of experimental approaches, ensuring its reliability and reproducibility. It has been shown to exhibit minimal cross-reactivity with non-phosphorylated forms of MKP-1 and MKP-2, as well as other related proteins, further enhancing its specificity.

The MKP-1/2(Phospho Ser296/318) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. Its long shelf life and stability ensure consistent and reliable results over an extended period of time.

In summary, the MKP-1/2(Phospho Ser296/318) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of phosphorylated MKP-1 and MKP-2 proteins. Its exceptional specificity, sensitivity, and reliability make it an invaluable asset for researchers studying the role of these proteins in various biological processes.