TPSAB1 monoclonal antibody

Tryptase is the most abundant neutral serine protease expressed in the secretory granules of all human mast cells. Tryptase is secreted upon the coupled activation-degranulation response of mast cells in peripheral tissues to physical factors such as trauma, toxins, venoms, endogenous mediators, and immune mechanisms (IgE-dependent and IgE-independent). Tryptase has distinct enzymatic functions that depend on the monomeric or homotetrameric state of this protein, the pH of the environment, and the presence or absence of heparin. Tryptase has the ability to cleave extracellular substrates such as vasoactive intestinal peptides, calcitonin gene-related peptides, fibronectins, fibrinogens, and kininogens. Tryptase is also a potent growth factor for epithelial cells, airway smooth muscle cells, and fibroblasts.