Wilms Tumor 1 monoclonal antibody

Wilms' Tumor 1 (WT1) is a transcription factor named from Wilms' Tumor 1, an embryonal malignancy of the kidneys that is caused by mutations in the WT1 gene . It is highly important in development, particularly of the genitourinary system, and mutations and dysregulation of expression of WT1 result in a variety of syndromes affecting the genitourinal system and other tissues.
WT1 has a myriad of biological functions and a host of interacting partners and target genes . It can behave as a transcriptional activator, or a repressor, and can act as an oncogene or a tumor suppressor . It exerts influence over the epigenetic landscape, and also has post translational influence of gene expression through RNA interactions . The diverse biological roles of WT1 have been attributed to the existence of multiple isoforms and post translation modifications of the protein.