CHD2 polyclonal antibody

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD proteins alter gene expression by modifying chromatin structure,thereby altering access of the transcriptional machinery to its chromosomal DNA template. Chromodomain helicase DNA binding protein 2, also known as CHD2, is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Consisting of 1,828 amino acids, CHD2 is expressed in the nucleus and contains two chromo domains, a helicase ATP-binding domain and a helicase C-terminal domain. CHD2 is suggested to play a critical role in development, hematopoiesis and tumor suppression. Mutations in the gene encoding CHD2 may be the cause of glomerulopathy, proteinuria and significantly impaired kidney function. CHD2 exists as two alternatively spliced isoforms.