ZMYND11 polyclonal antibody

The adenovirus E1A gene products are nuclear phosphoproteins with the ability to transactivate other adenovirus genes. BS69 specifically interacts with adenovirus 5 E1A and inhibits transactivation by the 289R E1A protein. BS69 interacts with the co-repressor N-CoR through an essential MYND domain in the carboxy terminus of N-CoR. BS69 also inhibits the transcriptional activity of c-Myb. During oncogenesis, this BS69/Myb regulatory circuit maybe be a target for disruption . Another ubiquitously expressed member of the Myb gene family, b-Myb, also interacts with BS69 and N-CoR to function as a transcriptional repressor. BRAM1, a splice variant of BS69, binds specifically to bone morphogenetic protein type IA receptor (BMPR-IA). BRAM1 localizes to the cytoplasm of mammalian cells, while BS69 localizes to the cell nucleus . Unlike BS69, BRAM1 is unable to repress transcription .