BCAP29 polyclonal antibody

BAP29 (BCR-associated protein 29), also known as BCAP29 (B-cell receptor-associated protein 29), is a multi-pass membrane protein localizing to the endoplasmic reticulum (ER) and belonging to the BCAP29/BCAP31 family of proteins. It is ubiquitously expressed with predominant expression in brain and testis. BAP29 contains a hydrophobic N-terminus, three transmembrane domains, a coiled-coil region and a C-terminal double-lysine motif that is implicated in vesicular transport. BAP29 exists as a homodimer or as a heterodimer with BAP31 and plays a role in membrane IgD molecule retention in the ER. In addition, the BAP29/BAP31 complex functions as a cargo receptor for MHC class I molecules and is important for recruiting the class I molecules to exit sites of the ER. The BAP29/BAP31 complex is also essential for proper trafficking from the ER to the Golgi.