FIBP polyclonal antibody

Fibroblast growth factors (FGFs) represent a family of over twenty distinct proteins that are ubiquitously expressed in mammalian systems. FGF activity influences development, adult tissue homeostasis, angiogenesis and cancer progression. The FGF-1 intracellular-binding protein (FIBP) is a 364 amino acid protein that binds to internalized FGF-1 and is thought to be involved in mitogenic function of FGF-1. FIBP localizes to the nucleus and is highly expressed in heart, skeletal muscle and pancreas and at lower levels in brain, placenta, liver and kidney. The gene encoding FIBP is expressed as two isoforms, designated long and short, which are produced as a result of alternative splicing events.