SEPHS1 polyclonal antibody

SEPHS1 (selenophosphate synthetase 1), also known as SELD, SPS or SPS1, is a 392 amino acid member of the selenophosphate synthetase 1 family and is one of two mammalian homologs of the eubacteria selenophosphate synthetase protein SelD. SelD is an enzyme that generates the selenium donor for the biosynthesis of selenocysteine, an amino acid that is co-translationally incorporated into selenoproteins at in-frame UGA codons. SEPHS1 has a similar function to SelD and specifically catalyzes the formation of selenophosphate (the active selenium donor) from selenide, ATP and H2O. Proper SEPHS1 function depends on a selenium salvage system that recycles L-selenocysteine, thereby providing the substrates for selenophosphate synthesis.