QPCT polyclonal antibody

QPCT (glutaminyl-peptide cyclotransferase) is a 361 amino acid protein that belongs to the glutaminyl-peptide cyclotransferase family. QPCT is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. QPCT binds one zinc ion per subunit and has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue. The human QPCT gene shares 86% overall sequence identity with the bovine homolog. QPCT contains an N-terminal signal peptide region, several glycosylation and phosphorylation sites and two cysteine residues conserved between the bovine and human enzymes. Existing as two alternatively spliced isoforms, the QPCT gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, fruit fly, mosquito, M.grisea and N.crassa, and maps to human chromosome 2p22.2.