TMOD4 polyclonal antibody

Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments . A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments . Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans. TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively. TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 . The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein . The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B.