AAK1 Polyclonal Antibody

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 encodes a member (AP2 associated kinase 1) of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

The AAK1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of AAK1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human AAK1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards AAK1 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and immunofluorescence.

The AAK1 Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its specificity and sensitivity. It is supplied as a purified IgG fraction, which has been affinity-purified using protein A chromatography. The antibody is provided in a liquid form, and is ready-to-use for various applications.

The AAK1 Polyclonal Antibody is an essential tool for researchers studying the role of AAK1 protein in various cellular processes such as endocytosis, cell migration, and cell proliferation. It is also useful for investigating the potential therapeutic applications of AAK1 inhibitors in various diseases such as cancer, neurodegenerative disorders, and viral infections.

Overall, the AAK1 Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results for the detection and quantification of AAK1 protein in various biological samples.