ABHD12 Polyclonal Antibody

ABHD12 encodes an enzyme (abhydrolase domain containing 12) that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in ABHD12 are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for ABHD12.

The ABHD12 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of ABHD12 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a region of the human ABHD12 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and ELISA.

The ABHD12 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. This ensures high purity and minimal cross-reactivity with other proteins. The antibody is also validated for use in various applications and has been extensively tested for its specificity and sensitivity. With its high quality and reliability, the ABHD12 Polyclonal Antibody is an essential tool for researchers studying the ABHD12 protein and its role in various biological processes.