Abl1 Polyclonal Antibody

ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein (ABL proto-oncogene 1, non-receptor tyrosine kinase)is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

The ABL1 Polyclonal Antibody is a meticulously crafted and highly specific immunological tool designed to facilitate accurate detection and analysis of ABL1 protein expression. This antibody is derived from a diverse pool of antibodies, ensuring a broad spectrum of recognition and binding capabilities. With its exceptional sensitivity and affinity, this polyclonal antibody enables researchers to explore the intricate functions and regulatory mechanisms of ABL1 in various biological contexts.

The ABL1 Polyclonal Antibody exhibits exceptional performance in a multitude of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its robust and reliable performance guarantees precise and reproducible results, making it an indispensable asset for both basic research and clinical investigations.

This antibody has been rigorously validated through extensive quality control measures, ensuring its consistency and reliability. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and specific detection of ABL1. Furthermore, it demonstrates excellent stability, allowing for long-term storage without compromising its performance.

The ABL1 Polyclonal Antibody is supplied in a convenient and user-friendly format, facilitating ease of use and minimizing experimental variability. Its exceptional quality and performance make it an ideal choice for researchers seeking to unravel the intricate molecular mechanisms involving ABL1. Trust in the ABL1 Polyclonal Antibody to provide unparalleled insights into the role of ABL1 in cellular processes and disease pathogenesis.