Acetyl Histone H2A (K5) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. H2AFZ encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

The Acetyl Histone H2A (K5) Polyclonal Antibody is a meticulously crafted and highly specific immunological tool designed for the detection and analysis of acetylated histone H2A at lysine 5 residue. This antibody exhibits exceptional sensitivity and selectivity, making it an indispensable asset for researchers in the field of epigenetics and chromatin biology.

With its polyclonal nature, this antibody offers a broad range of applications, including Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence. Its versatility allows for comprehensive investigations into the acetylation status of histone H2A at lysine 5, enabling a deeper understanding of the intricate mechanisms underlying gene expression regulation and chromatin remodeling.

The Acetyl Histone H2A (K5) Polyclonal Antibody has been rigorously validated to ensure optimal performance and reliability. It exhibits minimal cross-reactivity with other acetylated histone H2A residues, ensuring accurate and specific detection of acetylation at lysine 5. Furthermore, this antibody demonstrates excellent reproducibility, providing consistent and robust results across multiple experiments.

Manufactured using state-of-the-art techniques and high-quality materials, this antibody guarantees exceptional sensitivity and signal-to-noise ratio. Its superior affinity for acetylated histone H2A at lysine 5 ensures reliable detection even at low protein concentrations, facilitating precise quantification and analysis.

In summary, the Acetyl Histone H2A (K5) Polyclonal Antibody is an indispensable tool for researchers seeking to unravel the complexities of epigenetic modifications. Its exceptional sensitivity, specificity, and versatility make it an invaluable asset in the pursuit of understanding the role of acetylated histone H2A at lysine 5 in gene regulation and chromatin dynamics.