Acetyl p53 (K386) Polyclonal Antibody

TP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons.

The ACETYL P53 (K386) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of acetylated p53 protein. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional sensitivity and specificity in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The ACETYL P53 (K386) Polyclonal Antibody is meticulously developed to target the acetylated lysine 386 residue of the p53 protein, a crucial post-translational modification associated with its activation and function. This antibody exhibits exceptional affinity and selectivity towards acetylated p53, enabling accurate and precise detection of this modified form.

With its superior performance, the ACETYL P53 (K386) Polyclonal Antibody offers researchers a valuable tool for investigating the role of acetylated p53 in various biological processes, including cell cycle regulation, DNA repair, apoptosis, and tumor suppression. Its high specificity ensures minimal cross-reactivity with non-acetylated p53 or other proteins, guaranteeing reliable and reproducible results.

The ACETYL P53 (K386) Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows. It is provided in a liquid formulation, ensuring stability and ease of handling. Each batch of antibody undergoes rigorous quality control procedures to ensure consistent performance and reliability.

In summary, the ACETYL P53 (K386) Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of acetylated p53 protein. Its exceptional sensitivity, specificity, and versatility make it an indispensable asset for researchers studying the intricate mechanisms of p53 regulation and its implications in various biological processes.