ACHA2 Rabbit Polyclonal Antibody

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains| a variable cytoplasmic loop| a fourth conserved transmembrane domain| and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

The ACHA2 Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of ACHA2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ACHA2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards ACHA2 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and ELISA.

The ACHA2 Rabbit Polyclonal Antibody is purified using a combination of protein A and peptide affinity chromatography, ensuring high purity and minimal cross-reactivity with other proteins. This antibody has been extensively validated for its specificity and sensitivity in various biological samples, including human, mouse, and rat tissues.

The ACHA2 Rabbit Polyclonal Antibody is supplied as a lyophilized powder, which can be reconstituted in a buffer of choice for immediate use. This antibody is suitable for use in both research and diagnostic applications, and its high specificity and sensitivity make it an essential tool for studying the role of ACHA2 protein in various physiological and pathological processes. Overall, the ACHA2 Rabbit Polyclonal Antibody is a reliable and effective immunological reagent that can facilitate the advancement of scientific research and clinical diagnostics.