Actinin-Alpha1/2/3/4 Polyclonal Antibody

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for ACTN1.

The Actinin-Alpha1/2/3/4 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of actinin-alpha isoforms 1, 2, 3, and 4. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional sensitivity and specificity in various applications, including immunohistochemistry, western blotting, and immunofluorescence.

Actinins are a family of actin-binding proteins that play crucial roles in maintaining the structural integrity and organization of the cytoskeleton. Actinin-alpha isoforms are particularly important in the formation and stabilization of actin filament networks in muscle cells and other tissues. Dysregulation of actinin-alpha isoforms has been implicated in various pathological conditions, making their detection and analysis essential for understanding disease mechanisms.

The Actinin-Alpha1/2/3/4 Polyclonal Antibody exhibits high affinity and selectivity towards actinin-alpha isoforms 1, 2, 3, and 4, enabling precise and accurate identification of these proteins in complex biological samples. Its exceptional sensitivity allows for the detection of low-abundance actinin-alpha isoforms, facilitating comprehensive investigations into their expression patterns and cellular localization.

This antibody has been rigorously validated using a variety of experimental approaches, ensuring its reliability and reproducibility. It exhibits minimal cross-reactivity with other actinin isoforms and related proteins, further enhancing its specificity. Additionally, it demonstrates excellent performance in different experimental conditions, including various tissue types and species.

The Actinin-Alpha1/2/3/4 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. Its user-friendly format enables straightforward and efficient experimental procedures, saving valuable time and resources.

In summary, the Actinin-Alpha1/2/3/4 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of actinin-alpha isoforms 1, 2, 3, and 4. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers studying actinin biology and its implications in various physiological and pathological processes.