ADAMTS-2 Polyclonal Antibody

ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2) encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in ADAMTS2 cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

The ADAMTS-2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection and quantification of ADAMTS-2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ADAMTS-2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards ADAMTS-2 protein, making it an ideal tool for various research applications.

The ADAMTS-2 Polyclonal Antibody has been extensively validated for use in Western blotting, immunohistochemistry, and ELISA assays. It has been shown to detect ADAMTS-2 protein in a variety of tissues and cell lines, including lung, heart, kidney, and liver. This antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng/mL in ELISA assays.

In addition to its high specificity and sensitivity, the ADAMTS-2 Polyclonal Antibody is also highly reproducible and reliable. It has been rigorously tested for cross-reactivity with other proteins and has been shown to exhibit minimal cross-reactivity with other members of the ADAMTS family.

Overall, the ADAMTS-2 Polyclonal Antibody is a valuable tool for researchers studying the role of ADAMTS-2 protein in various biological processes. Its high specificity, sensitivity, and reproducibility make it an ideal choice for a wide range of applications, including basic research, drug discovery, and clinical diagnostics.