ADD1 Polyclonal Antibody

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

The ADD1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of ADD1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a region of human ADD1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards ADD1 protein, making it an ideal tool for various applications in research and diagnostics.

The ADD1 Polyclonal Antibody is validated for use in Western blotting, immunohistochemistry, and ELISA assays. It has been shown to detect endogenous ADD1 protein in human tissues and cell lines with high sensitivity and specificity. This antibody is also suitable for use in other applications such as immunoprecipitation and flow cytometry.

The ADD1 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum. It is provided in a liquid format and can be stored at -20°C for long-term use. This antibody is available in various sizes and formats to meet the needs of different applications.

In summary, the ADD1 Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of ADD1 protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers and clinicians working in the fields of neuroscience, cardiovascular disease, and cancer research.