Adducin Beta Polyclonal Antibody

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

The Adducin Beta Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Adducin Beta protein in various biological samples. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reproducibility.

The Adducin Beta Polyclonal Antibody exhibits exceptional sensitivity and specificity, making it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes the Adducin Beta protein with high affinity, enabling accurate and precise quantification of its expression levels.

This antibody is manufactured using state-of-the-art recombinant technology, resulting in a highly purified and concentrated product. It is supplied as a liquid formulation, ready for immediate use without the need for any additional preparation or reconstitution.

The Adducin Beta Polyclonal Antibody has been extensively validated and tested in various experimental conditions to ensure its reliability and consistency. It exhibits minimal cross-reactivity with other related proteins, ensuring specific and accurate detection of Adducin Beta.

With its exceptional performance and reliability, the Adducin Beta Polyclonal Antibody is an indispensable tool for researchers and scientists working in the fields of cell biology, molecular biology, and biochemistry. It provides valuable insights into the role and function of Adducin Beta in various physiological and pathological processes.

Order the Adducin Beta Polyclonal Antibody today and unlock the potential of your research by obtaining accurate and reliable data on Adducin Beta protein expression and localization.