Adducin Gamma Polyclonal Antibody

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.

The Adducin Gamma Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of adducin gamma protein in various biological samples. This antibody is produced using advanced recombinant technology, ensuring exceptional quality and performance.

The Adducin Gamma Polyclonal Antibody exhibits a high affinity towards its target protein, enabling accurate and sensitive detection. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its exceptional specificity, this antibody allows for precise identification and quantification of adducin gamma protein in complex biological systems. It offers researchers a valuable tool for studying the role of adducin gamma in cellular processes and disease mechanisms.

The Adducin Gamma Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing waste. Each batch of this antibody undergoes rigorous quality control procedures to ensure consistent performance and reproducibility.

In summary, the Adducin Gamma Polyclonal Antibody is a reliable and specific tool for the detection and analysis of adducin gamma protein. Its exceptional quality, sensitivity, and versatility make it an ideal choice for researchers in the field of molecular biology, cellular biology, and biomedical research.